The Clinical Affective Neuroscience (CAN) Laboratory is located in the Memory and Aging Center at the University of California, San Francisco (UCSF) and is affiliated with the UCSF Center for Psychophysiology and Behavior (CPB). The goal of our research is to advance our understanding of the neurobiological basis of affective symptoms, which are a common and debilitating feature of many neurological and psychiatric disorders. We use multiple methods from affective science (e.g., psychophysiology, facial behavior, and self-reported experience) to quantify emotion in neurodegenerative diseases, psychiatric illnesses, neurodevelopmental disorders, and healthy individuals. By combining laboratory-based autonomic and behavioral measures with magnetic resonance imaging, we examine how neural system integrity relates to alterations in emotion and social functioning.